PICO Question Examples

PICO Question Examples

PICO Question Examples
PICO Question Examples

20 PICO Question Examples

  1. In patients with type 2 diabetes, does treatment with metformin reduce the risk of cardiovascular disease compared to treatment with sulfonylurea drugs?
  2. In adults with hypertension, is blood pressure control achieved more effectively with angiotensin converting enzyme inhibitors or with calcium channel blockers?
  3. In postmenopausal women, does hormone replacement therapy increase the risk of breast cancer compared to placebo?
  4. In patients with acute respiratory distress syndrome, does the use of mechanical ventilation with lower tidal volumes reduce mortality compared to traditional tidal volumes?
  5. In patients with major depressive disorder, does cognitive behavioral therapy lead to greater improvement in symptoms compared to antidepressant medication?
  6. In children with attention-deficit/hyperactivity disorder, does stimulant medication improve academic and behavioral outcomes compared to behavioral therapy alone?
  7. In patients with severe acne, does isotretinoin treatment result in longer lasting remission compared to oral antibiotics?
  8. In patients with chronic low back pain, does acupuncture provide greater pain relief than sham acupuncture?
  9. In patients with chronic obstructive pulmonary disease, does pulmonary rehabilitation improve exercise capacity and quality of life compared to standard medical care alone?
  10. In patients with osteoarthritis of the knee, does total knee replacement result in greater improvement in pain and function compared to non-surgical management?
  11. In patients with stroke, does the use of intravenous thrombolysis within 3 hours of symptom onset improve functional outcome compared to placebo?
  12. In patients with HIV, does antiretroviral therapy reduce the risk of transmission to sexual partners compared to no treatment?
  13. In patients with type 1 diabetes, does continuous glucose monitoring improve glycemic control compared to self-monitoring of blood glucose?
  14. In patients with acute myocardial infarction, does primary percutaneous coronary intervention result in improved survival compared to fibrinolytic therapy?
  15. In patients with advanced cancer, does palliative care improve quality of life and decrease symptom burden compared to standard cancer treatment alone?
  16. In patients with chronic obstructive pulmonary disease, does long-term oxygen therapy improve survival compared to no oxygen therapy?
  17. In patients with schizophrenia, does the use of atypical antipsychotic medications result in greater improvement in symptoms compared to typical antipsychotic medications?
  18. In patients with alcohol use disorder, does psychosocial intervention reduce the risk of relapse compared to pharmacotherapy alone?
  19. In patients with chronic kidney disease, does early referral to a nephrologist improve outcomes compared to delayed referral?
  20. In patients with type 2 diabetes, does a low carbohydrate diet result in greater weight loss and improvement in glycemic control compared to a low fat diet?

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